EVALUATION OF ANTI-ULCER ACTIVITY OF ETHANOLIC EXTRACT OF OECOPHYLLA SMARADINA IN ALBINO RATS
AbstractObjective: Oecophylla smaradina (Formicidae) is an ant evaluated for its variety of medicinal uses. The objective of this study to evaluate the anti-ulcer activity using albino rats. Methods: The albino rats of either sex were divided into four groups. Ethanolic extract of Oecophylla smaradina (EEOS) was tested in the dose of 200 and 400 mg/kg p.o. respectively against by pylorus ligation induced ulcer models in albino rats. Results: Both the concentration (200 and 400 mg/kg p.o.) of extract have provided significant activity but EEOS 200 mg/kg, p.o, extracts were less effective when compared to EEOS 400 mg/kg, p.o. The antiulcer activity was accessed by evaluate the ulcer index in the test and standard drug treated group and also estimated the gastric volume, total acid, and free acid in the pylorus-ligated rats. Conclusion: The present study was revealed that ethanolic extract of Oecophylla smaradina have antiulcer activity.
Article Information
53
3946-3950
648
693
English
IJPSR
P. Natarajan *, R. S. Singh and K. Balamurugan
Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India.
natarajanmpharm@gmail.com
06 December 2018
13 March 2019
01 April 2019
10.13040/IJPSR.0975-8232.10(8).3946-50
01 August 2019
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