EVALUATION OF ANTI ULCER AND IN-VITRO ANTIOXIDANT ACTIVITIES OF AQUEOUS AND METHANOLIC EXTRACTS OF NEOLAMARCKIA CADAMBA LEAVES AND BARK IN WISTAR ALBINO RATSAbstract
The antiulcer activity of Aqueous and Methanolic extracts of Neolamarckia cadamba leaves and bark was investigated in Pylorus ligation and Aspirin induced ulcer models in Wistar albino rats. In both models the common parameter determined was ulcer index. Aqueous extract of Neolamarckia cadamba leaves (AENCL) at dose of 200mg/kg and 400 mg/kg produced significant inhibition of gastric lesion induced by Pylorus ligation induced ulcer and Aspirin induced gastric ulcer. The AENCL (200mg/kg and 400mg/kg) showed significant (p<0.05) reduction in gastric volume, pH, free acidity, Total acidity, ulcer index and % ulcer inhibition was compared to control. This present study indicates that AENCL and Methanolic extract of Neolamarckia cadamba leaf (MENCL) have potential antiulcer activity in both models. These results may further suggest that the AENCL and MENCL possess antiulcerogenic as well as ulcer healing properties which might be due to its antisecretory activity. Antioxidant activity was evaluated for free radical scavenging activity by DPPH assay which showed the significant antioxidant activity of AENCL and MENCL further supported their antiulcerogenic property.
Vinay Kumar Inaparthi*, Patibandla Naresh Babu, Prasad K, Nagaraju B, Prasanthi K, Srinivasa
Department of Pharmacology, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram, West Godavari, Andhra Pradesh, India
02 December, 2013
21 January, 2014
16 March, 2014
01, May 2014