EVALUATION OF ANTIASTHMATIC ACTIVITY OF CITRULLUS COLOCYNTHIS FRUITAbstract
The present investigation was under taken to evaluate the anti-asthmatic activity of ethanolic extract of Citrullus colocynthis Fruits in experimental animals. Citrullus colocynthis Fruits was evaluated for anti-histaminic activity using isolated goat tracheal chain preparation and histamine induced Bronchoconstriction in Guinea pig. Citrullus colocynthis Fruits significantly inhibited dose dependent contraction of goat tracheal chain produced by histamine and also showed significant protection by prolonging Preconvulsion dyspnea time (PCD) in guinea pigs. Thus, Citrullus colocynthis Fruits showed anti-allergic activity against histamine and hence possesses potential role in the treatment of asthma.
Chandan Genwa *, Umesh K. Gilhotra, Anil K. Varma and Bhawna Rajpurohit
G. D. Memorial College of Pharmacy, Jodhpur, Rajasthan, India.
08 August, 2016
13 September, 2016
17 November, 2016
01 February, 2017