EVALUATION OF ANTIASTHMATIC ACTIVITY OF TECTONA GRANDIS LINN. BARKAbstract
Various extracts of Tectona grandis Linn. bark were screened for antiasthmatic activity by using different in-vivo animal models like clonidine induced catalepsy, haloperidol induced catalepsy, milk induced leucocytosis and eosinophilia. The observation of this study indicated that the Tectona grandis bark having antihistaminic activity inhibited clonidine-induced catalepsy and not inhibited haloperidol-induced catalepsy. The results of these studies indicated that ethyl acetate extract of Tectona grandis Linn. Bark showed significant (p< 0.001) antiasthmatic activity at the dose of 100 mg/kg. The anti-asthmatic activity of ethyl acetate extract can be attributed to antihistaminic (H1-antagonist), antimuscarinic, antiallergic, anti-inflammatory and adaptogenic activity suggestive of its potential in management of asthma.
Dhirendra V. Goswami et al.
Department of Pharmacognosy, Pravara Rural College of Pharmacy, Loni, (M.S.) India
4 December, 2009
20 December, 2009
28 December, 2009
01 January, 2010