EVALUATION OF ANTIDIABETIC ACTIVITY OF PELTOPHORUM PTEROCARPUM ON ALLOXAN AND GLUCOSE INDUCED DIABETIC MICEAbstract
The present study was designed to determine the antidiabetic activity of the methanol: ethyl acetate (1:9) extract of flower buds of Peltophorum pterocarpum on alloxen and glucose indueced diabetic mouse model. The extract was given intraperitonially at a dose of 200 mg/kg body weight and the hypoglycemic effects compared with metformin, a standard drug. The extract reduced blood glucose level in alloxan-induced diabetic mice by 60.40%, and 65.48% reduced by metformin at 12 hours in 24 hours treatment period. Preliminary phytochemical screening of the extract revealed the presence of different types of compounds including flavonoids and steroids. Our results suggest that Peltophorum pterocarpum has potential antidiabetic activity and may provide new molecules for the treatment of diabetes.
Md. Saiful Isalm*, Md. Rafikul Islam , Md. Masudur Rahman , Md. Sekendar Ali , Ashik Mosaddik and Golam Sadik
Lecturer, Department of Pharmacy, International Islamic University Chittagong, Chittagong, Bangladesh
28 February, 2011
21 April, 2011
16 May, 2011
01 June, 2011