EVALUATION OF ANTIFERTILITY ACTIVITY OF ACHYRANTHUS ASPERA LEAVES IN FEMALE MICEAbstract
Present study was conducted to know the antifertility potential of Achyranthus aspera leaves in female mice and has shown promising results of antiovulatory activity, estrogenic and constant teratogenic activities. Administrations of A. aspera leaves methanolic extract at the dosage 25 mg/kg and 50 mg/kg body weight were subjected for testing their antiovulatory, estrogenic and teratogenic activity in female mice by applying statistical analysis in gravimetric, biochemical and histopathological parameters of ovary and uterus. At autopsy on day 31st, both the dose treated mice revealed increase in ovarian weight, histological changes like increasing number of atretic follicle and decreases in healthy developing follicles, Graafian follicles and corpora lutea. Total cholesterol content and alkaline phosphatase of the ovary were increased and protein, glycogen, acid phosphatase content were decreased. Teratogenic activity did not alter any changes in the morphological and physiological behavior of experimental period. Results suggested that, methanolic extract of A. aspera leaves are more active at low dose compared to high dose and might be used as an herbal contraceptive in females.
Chinnappa Reddy V., Abhay Kumar Kamble and Sharangouda J. Patil *
Edutel Technologies Private Limited, Yeshwantpur Industrial Subrub, Yeshwantpur, Bangalore, Karnataka, India
02 May, 2016
11 June, 2016
29 June, 2016
01 September 2016