EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF METHANOLIC LEAVES EXTRACT OF LASIA SPINOSA AND ITS ROLE IN PREVENTION OF HYPERLIPIDEMIA INDUCED PANCREATITIS IN RATSAbstract
Leaves, rootstock, fruit and decoction of Lasia spinosa (Araceae) are used in folklore medicine for Gastrointestinal, Respiratory and Skin diseases. The intent of the present study was to evaluate the Antihyperlipidemic activity of methanolic leaves extract of Lasia spinosa and for its role in the prevention of hyperlipidemia induced pancreatitis in rats. The evaluation of the Antihyperlipidemic activity and the role of Lasia spinosa in the prevention of hyperlipidemia induced pancreatitis were done by means of Cholesterol 100 mg/kg body weight, p.o, induced hyperlipidemic model and Triton-X 100 (480 mg/kg, b.w; i.p.) induced hyperlipidemic model. The biochemical parameters such as Total Cholesterol, Triglycerides, LDL-C, HDL-C, VLDL-C, Serum Amylase, Serum Lipase and WBC Count were estimated to appraise its activity. A significant increase in the levels of biochemical and biological parameters was discerned in group 2 and a reversal in the extent was seen in the treated group of animals engaged in the study. The histopathological evaluations of Liver and Pancreas samples were in support of the obtained results. Based on the above results it can be suggested that Lasia spinosa leaves possess anti Hyperlipidemic activity and has the potential in prevention of hyperlipidemia induced pancreatitis.
S. B. Mahmood*, Md. Atif, Syed Rashid Ali, Md. Ibrahim Ahmed and Shaik Abdul Rahman
Shadan College of Pharmacy, Peerancheru, Hyderabad, Telangana, India
03 August, 2014
24 October, 2014
27 December, 2014
01 April, 2015