EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF NYMPHAEA ALBAAbstract
Hyperlipidemia is the greatest risk factor of coronary heart disease, currently available hypolipidemic drugs have been associated with number of side effects. Literature claims that flavonoids are able to reduce hyperlipidemia. Based on high flavonoids content in herbal plants, Nymphaea alba (NA) family Nymphaeaceae were selected and the present study focus on the antihyperlipidemic activity of methanol extract of leaves of NA against triton induced hyperlipididemia in rats. NA was administered at a dose of 100mg &200mg /kg (p.o) to triton induced hyperlipidemic rats. Fenofibrate was used as a reference standard. The statistical analyses were carried out using one way ANOVA followed by dunnets multiple comparisions test. NA shows a significant decrease in the levels of serum cholesterol, phospholipids, triglyceride, LDL, VLDL and significant increase in the level of serum HDL at the dose of 100 & 200mg/kg (p.o) against trition induced hyperlipidemic in rats. Methanol extracts decreased serum level of total cholesterol by 74.25%. On the other hand aqueous extract of NA increased the serum HDL cholesterol level by 23.27%. The reduction of LDL cholesterol level by extract was 32.76%.
N. Jaya Raju *, B. Satya Vani , G. Santhi , L. Lavanya and T. Chandi Vishala
Adarsa College of Pharmacy 1, G. Kothapalli, Gokavaram(m), East Godavari dt, Andhra Pradesh, India
03 March, 2016
16 May, 2016
08 July, 2016
01 August 2016