EVALUATION OF ANTIMICROBIAL ACTIVITIES AND DNA-BINDING PROPERTIES OF MOLYBDENUM COMPLEXESAbstract
Molybdenum is a trace element distributed widely in nature which plays an important role in plant and animal nutrition and in our industrial society. Molybdenum is essentially present in the enzymes nitrogenase, Xanthine-oxidase, sulphite oxidas, nitrate reductase, formate dehydrogenase and aldehyde oxidase. These enzymes are responsible for a number of catalytic reactions of redox nature. Molybdenum complexes were synthesized and characterized for their purity by various physico-chemical methods like IR, Electronic, 1H1 NMR spectral studies Antimicrobial activity of compounds against certain microbial species has been carried out by serial dilution method using BOD incubator to evaluate the MIC (Minimum Inhibitory Concentration) value on the basis of MIC value it is interpretated that Molybdenum complexes are most active as compared to ligand fragments. The DNA binding ability of the complexes was examined by using biophysical spectroscopic studies. These studies indicate that the compounds can intercalate and stablize DNA. This work has great importance in the field of bioinorganic relevance.
V. K. Srivastava
Chemical Research Laboratory, Department of Chemistry, D.S. College, Aligarh-202001, U.P., India
22 August, 2014
09 November, 2014
30 December, 2014
01 April, 2015