EVALUATION OF ANTIOXIDANT ACTIVITY OF LEAVES EXTRACT OF MORINGA CONCANENSIS NIMMO ON ISOLATED FROG’S HEARTAbstract
Moringa Cocanensis Nimmo is one of the important medicinal plants belonging to the family moringaceae. Moringa Cocanensis Nimmo has antipyretic, antihelmintic, antimicrobial, hepatoprotective, and anticancer activities. It is one of the most noted systems of medicine in the world. Ayurveda is based on the hypothesis that everything in the universe is composed of five basic elements viz. space, air, energy, liquid, and soil. The traditional system was proved to be more effective when compared to synthetic drugs due to reduction in side effects, adverse effects, and even a little increase in dose was not that dangerous when compared to the synthetic drugs. It was even found to be more economical and safer in all means. Hence, we have choosed the plant Moringa Concanensis Nimmo, evaluated its medicinal property and proved its antioxidant nature for replacing synthetic drug formulations. When ringer solution containing H2O2 perfused to heart preparation, the muscaranic actions of acetylcholine were not observed much, indicating the oxidative stress on frog heart induced by H2O2; this might be due to the desensitization of receptors. The cardiac arrest was proposed at 19.25th min. This result supports the frog heart model for induction of oxidative stress by H2O2. In the presence of the extract of the plant, cardiac arrest was observed at 27, 30 min respectively, i.e., heart was protected longer period with plant juice, against H2O2 induced oxidative stress when compared with the control.
Sridhar Vanga * and Shravan Kumar Dholi
Department of Pharmaceutical Chemistry, Beside LMD Police Station, Ramakrishna Colony, Karimnagar, Telangana, India.
03 November 2020
04 March 2021
23 June 2021
01 October 2021