EVALUATION OF ANTIOXIDANT AND ANTIHYPERLIPIDEMIC ACTIVITY OF EXTRACT OF GARCINIA INDICAAbstract
Garcinia indica is well spread in tropical rain forest of Western Ghats of India. Extract of dried fruit rind of kokum was prepared using methanol. Extract was evaluated for antioxidant and antihyperlipidemic activity. Garcinia was tested for antihyperlipidemic activity using cholesterol induced hyperlipidemic model in Albino Wistar rats. It exhibited significant reduction in total cholesterol, triglycerides, LDL-C, VLDL-C levels and increase in level of HDL-C when compared to Lovastatin. Artherogenic index and LDL-C: HDL-C ratio was also reduced to significant extent. Significant antioxidant and antihyperlipidemic activity may be due to the presence of polyphenols like Garcinol and hydroxycitricacid in Garcinia.
Kamil K. Darji, Pritam Shetgiri and P. M. D’mello*
Department of Pharmacognosy and Phytochemistry, Prin. K. M. Kundnani College of Pharmacy, Cuffe Parade, Colaba, Mumbai, Maharashtra, India
27 July, 2010
11 October, 2010
13 November, 2010
01 December, 2010