EVALUATION OF ANTIOXIDANT PARAMETERS OF MUKIA MADERASPATANA

The present study was an attempt to investigate the effect of extracts and fractions of Mukia maderaspatana on glycemia, lipid profile, lipoprotein level and antioxidant profile in STZ induced diabetic rats for 21 days. Diabetes was induced using streptozotocin (50 mg/kg i.p) and after the induction of diabetes the animals were given with MMEE (100 mg/kg, 200 mg/kg), MMCF (100 mg/kg) and MMBF (100 mg/kg) orally for 21 days. Blood glucose levels were determined by using GOD-POD method with diagnostic kits. The lipid and lipoprotein level was estimated by using the respective kits. The administration of the extracts orally for 21 days showed that there was an amelioration of the lipid and lipoprotein levels significantly. After 21 days the parameters like HDL, LDL, VLDL, TC, TG, Albumin, Creatinine, total protein and glucose were estimated. The treatment with the extracts and fractions of Mukia maderaspatana improved the lipid level and lipoprotein level to a normal condition which may be attributed to its potent antidiabetic activity. The levels of urea and creatinine were significantly decreased after the treatment of STZ diabetic rats with MMEE, MMCF, and MMBF. The treatment of diabetic rat with Mukia maderaspatana caused a noticeable elevation in serum total protein and albumin levels as compared with normal levels. The treatment with MMEE, MMCF, and MMBF ameliorated the changes induced by STZ.