EVALUATION OF ANTIPEROXIDATIVE POTENTIAL OF ASCORBIC ACID ON BUSULFAN-INDUCED LIPID PEROXIDATION USING 4-HYDROXY-2-NONENAL AND NITRIC OXIDE AS MODEL MARKERSAbstract
The study was designed with an aim to evaluate the antiperoxidative potential of ascorbic acid on busulfan-induced lipid peroxidation. The study was performed in vitro using goat liver as lipid source. This evaluation was done by measuring the 4-hydroxy-2-nonenal (4-HNE) and nitric oxide (NO) content of liver tissue homogenates as markers of lipid peroxidation. The study reveals the lipid peroxidation induction capacity of busulfan and the antiperoxidative potential of ascorbic acid on busulfan-induced lipid peroxidation.
Professor & HOD, Division of Pharmaceutical Chemistry, Dr. B C Roy College of Pharmacy & Allied Health Sciences, Bidhannagar, Durgapur- 713 206, West Bengal, India
19 November, 2011
25 December, 2011
23 February, 2012