EVALUATION OF ANTIULCER ACTIVITY OF CALOTROPIS GIGANTEA R.Br LEAVESAbstract
The antiulcer activity of ethanolic extract of Calotropis gigantea R.Br leaves (EECG) was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Ethanolic extract of Calotropis gigantea at a dose of 150 and 300mg/kg produced significant inhibition of the gastric lesions induced by pylorus ligation induced ulcer and ethanol induced gastric ulcer. The extract (150mg/kg and 300mg/kg) showed significant (p<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that EECG have potential anti-ulcer activity in both models. These results may further suggest that the extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.
P. Swapna*, Stellaa Robertson A. Elumalai , M. Chinna Eswaraiah and K. Nirmala
Assistant Professor, Department of Pharmacognosy, Anurag Pharmacy College 2, Ananthagiri (v), Kodad(M), Nalgonda (Dt)- 508 206, Andhra Pradesh, India
16 July, 2011
08 August, 2011
19 October, 2011
01 November, 2011