EVALUATION OF ANXIOLYTIC ACTIVITY OF HYDROALCOHOLIC ACTIVITY OF TEPHROSIA PURPURIA (L) PERS ON SWISS ALBINO MICEAbstract
The present work is to evaluate the anxiolytic activity of a hydroalcoholic extract of Tephrosia purpuria (L) Pers (HAETP) in mice using the elevated plus-maze (EPM), elevated zero-maze (EZM), Y-maze and hole-board models. Furthermore, the anxiolytic effects of HAETP were compared to a known active anxiolytic drug diazepam. The extract, administered orally, in two different doses of HAETP 200 mg/kg and 400 mg/kg, was able to increase the time spent and the number of arm entries in the open arms of the elevated plus-maze and elevated zero-maze, as well as decrease the visits by mice in the Y-maze, also significantly increase nose poking, line crossing and rearing in hole-board. This effect was comparable to that of the diazepam (2.0 mg/kg i.p.). These results indicate that hydroalcoholic extract Tephrosia purpuria (L) Pers is an effective anxiolytic agent.
A. Sathish Kumar*, P. Amudha and C. Satheesh Kannan
Department of Pharmacology, C. L. Baid Metha College of Pharmacy, Chennai, Tamil Nadu, India
12 February, 2011
11 March, 2011
12 April, 2011
01 May, 2011