EVALUATION OF BENEFICIAL EFFECTS OF MORINDA CITRIFOLIA L. IN PRESENCE OF CISPLATIN ON EHRLICH’S ASCITES CARCINOMA BEARING MICEAbstract
Morinda citrifolia L. (Rubeaceae) is a medicinal plant commonly called as Noni. Traditionally the entire plant is used for the treatment of cancer, inflammation, hypertension, diabetes, bacterial infections, and arthritis. The present study aims to explore the antineoplastic activity of Noni Juice (NJ) and Divine Noni Gold (DNG) concentrate on Ehrlich ascites carcinoma (EAC) bearing mice. Antineoplastic activity of NJ and DNG was evaluated in EAC bearing mice by administrating 0.35 ml/mouse p.o. respectively once daily for 14 days, before half an hour of NJ and DNG administration animal received single dose of cisplatin (CP) at the dose of 5.0 mg/kg b.w. i.p. on day 1 in respective cluster. Antitumor activity of NJ and DNG were measured by evaluating Mean Survival Time (MST), percentage Increase in Life Span (%ILS), body weight, tumor volume and viable cell count, additionally biochemical markers as well as hematological parameters were also evaluated. In the result, observed NJ and DNG respectively showed significant decrease tumor volume, viable cell count, body weight and raised MST and %ILS. Hematological parameters and serum biochemical markers were reverted and maintained closed to normal level in CP challenged mice. Results indicates that NJ and DNG possesses antineoplastic activity, this impact may be for the sake of their antioxidant and anti-angiogenic properties. In conclusion, NJ and DNG may be beneficial supplements in CP chemotherapy for enhancing the antitumor efficacy and decreasing the toxicity of CP.
M. Ali, K. Mruthunjaya, C. Nandini, M. Nabeel, R. Anjali and S. N. Manjula*
Department of Pharmacology, JSS College of Pharmacy, JSS University, Mysuru, Karnataka, India.
02 May, 2017
17 July, 2017
25 July, 2017
01 January, 2018