EVALUATION OF CENTRAL AND PERIPHERAL ANALGESIC ACTIVITIES OF SOLANUM MELONGENA ETHANOLIC LEAF EXTRACT IN EXPERIMENTAL ANIMALS.Abstract
The aim of the study was to evaluate the central and peripheral analgesic activities of Solanum melongena ethanolic leaf extract in experimental animals. The Solanum melongena leaves were air dried at room temperature and were ground to a fine powder. Ethanolic extract was obtained by percolating the dried powder with 95% ethanol. Oral toxicity test was done according to OECD guidelines. For evaluation of central analgesic activity hot plate and tail flick methods were performed. These methods were carried out in healthy albino rats (Rattus norvegicus) of either sex weighing 100-200 gm. Thirty animals were used in each method. They were divided into five groups with six animals in each group for both methods. Solanum melongena ethanolic leaf extracts (500mg/kg) was used as test drug and Pethidine (5mg/kg) was used as the standard drug in these methods. For evaluation of peripheral analgesic activity, acetic acid induced writhing test was performed in albino mice. Total 18 healthy albino mice of either sex weighing 20–30 gm were used. They were divided into three groups with six animals in each group. In this method Solanum melongena ethanolic leaf extract (500mg) was used as test drug and Aspirin 100mg/kg was used as the standard drug. Solanum melongena ethanolic leaf extract showed significant (p<0.01) analgesic activity, both central and peripheral when compared to the control.