EVALUATION OF DATE PALM POLYSACCHARIDE (DPP) AS A BIOMUCOADHESENT AND ITS COMPARISON WITH VARIOUS MUCOADHESIVE POLYMERSAbstract
The mucoadhesive disks of various polymers were fabricated with objective of comparing the mucoadhesive strength and mucoretentability with the isolated DPP. The mucoadhesive polymers used in formulations were sodium carboxy methyl cellulose, carbopol (cp934), hydroxyl propyl methyl cellulose (HPMC K4M), and date palm fruit pulp polysaccharide (DPP). These formulations were characterized for physiochemical parameters, in vitro retention time, in vitro bioadhesive strength, Friability etc. The modified in vitro assembly was used to measure the mucoadhesive strength of disks with fresh goat and porc buccal mucosa as a model tissue. Mucoadhesive study showed that it possess a novel inbuilt significant mucoadhesive property therefore this biomaterial can serve as promising mucoadhesent for formulating the various transmucosal drug delivery systems.
Pragati Shakya*, N. V. Satheesh Madhav and Ashok K. Shakya
Faculty of Pharmacy, Integral University, Kursi Road, Lucknow, Uttar Pradesh, India
20 June, 2010
19 August, 2010
18 September, 2010
01 October, 2010