EVALUATION OF ERYTHROPOIETIN AS NEUROPROTECTANT IN ALCOHOL-INDUCED PERIPHERAL NEUROPATHY IN RATSAbstract
Alcoholic peripheral neuropathy is a potentially incapacitating complication of long-term excessive consumption of alcohol characterized by pain and dysesthesias, primarily in the lower extremities. The neurological effects of ethanol consumption are complex, encompassing both the central and peripheral nervous systems. It breaks into acetaldehyde which impairs and destroys the majority of neuronal functions. As a result, signals become intensified from the injured neurons and the nearby surrounding neurons, resulting in a painful condition. The study aims to evaluate the different doses of Erythropoietin, i.e., 250U/kg and 500U/kg, in alcohol-induced peripheral neuropathy. The present study involved evaluating the neuroprotective activity of Epo in alcohol-induced PN in rats by assessing behavioral, biochemical and electrophysiological, liver function tests, parameters. This study concludes that the two doses of Epo improved sciatic nerve conduction, behavioral studies and antioxidant activity in sciatic nerve homogenate. Among the two different doses of Epo, 500U/kg was most effective besides showing neuroprotective properties against alcohol-induced PN.
K, Arpitha, M. G. Hariprasad *, M. G. Mubasheera and Apurwa Dhavale
Department of Pharmacology, KLE College of Pharmacy Bangalore, Karnataka, India.
31 August 2021
31 October 2021
17 November 2021
01 June 2022