EVALUATION OF GASTRIC ANTIULCEROGENIC ACTION OF VEGETABLE PLANTAIN BANANA (MUSA SAPIENTUM VAR. PARADISIACA) IN ASPIRIN PLUS PYLORUS LIGATED ALBINO RATSAbstract
Objectives: To assess the effect of unripe dried banana powder in experimentally induced gastric ulcers and effect on gastric acid secretion. To evaluate the antiulcerogenic effect of plantain banana of Gujarat as a part of evaluation of impact of biological variables on this activity.
Results: Orally administered banana powder in the dose of 2gm/kg caused a statistically significant decrease in aspirin with pyloric ligation induced ulcers in rats without significantly decrease in secretary activity.Materials and methods: Total of 24 albino rats of either sex weighing between 150-250 gm were randomly divided into 4 groups. Each group has 6 no. of rats. The first group received placebo (distilled water), the second, third & forth group received 0.5gm/kg, 1gm/kg and 2mg/kg of banana powder respectively. Banana powder was given as suspension at fixed time (3 times in a day) for two days and animals were kept for fasting for another 48hrs. On 5th day, the animals were sacrificed after 7 hrs and stomach were removed for examination and gastric juice samples were collected to analyze volume and acidity.
Conclusion: It can be concluded from these results that vegetable plantain banana has antiulcerogenic and mucosal protective actions, but it has no antisecretory activity.
K.R. Tandel* and B.K. Shah
C-202, Green Enclave, Nr Sardar Bridge, Gujarat Gas Circle, Adajan, Surat- 395 009, Gujarat, India
20 July, 2012
17 August, 2012
30 October, 2012