EVALUATION OF HYDROXYPROPYLMETHYLCELLULOSE (HPMC) HYDROGEL MATRIX FOR DELIVERY OF TRIAMCINOLONEAbstract
The main purpose of this study was to evaluate hydrogel matrix systems of hydroxypropylmethylcellulose (HPMC) for oral release of poorly water-soluble drugs, by using triamcinolone (TR) as drug model. The influence of HPMC ratio (%) and compaction force (Kgf) on system performance were studied. Thus, several batches of tablets containing 10 mg of TR were prepared using distinct proportions of HPMC (30, 50 and 60 %; w/w), and characterized by: dimensions, weight, hardness, friability, disintegration time, swelling and dissolution. Regarding the dissolution profiles, several mathematical models were tested and the experimental data were fitted to a zero-order release. Additionally, the correlation between the swelling kinetics and the drug dissolution rate was established, suggesting the importance of the dependency of drug release from the swelling profile for all tested systems. However, there were not improvements for the system containing HPMC ratio higher than 30 % (w/w). To conclude, for the comparative evaluation of the system’s properties, the best technological conditions achieved were for the matrix produced under 7.5 kgf and using 30% HPMC.
Vivian Vollet de Morais, Alice Rodrigues de Oliveira, Magda Rhayanny Assuncao Ferreira, Fabio Araujo Bezerra, Pedro Jose Rolim Neto, Tatiane Pereira de Souza, Arnobio Antonio da Silva Junior, Luiz Alberto Lira Soares
Laboratorio de Farmacognosia, Departamento de Ciencias Farmaceuticas, UFPE Av. Arthur de Sa, s/n, 50740-521, Recife, PE, Brazil.
14 May, 2014
23 July, 2014
20 August, 2014
01 December 2014