EVALUATION OF HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY OF 50% HYDRO ETHANOLIC LEAF EXTRACT OF BARLERIA CRISTATA L. IN ALLOXAN INDUCED DIABETIC AND HIGH LIPID DIET FED RATSAbstract
The present study was carried out to evaluate the hypolipidemic and hypoglycemic effects of the plant Barleria cristata L. Phytochemical screening of crude powdered leaf extract of Barleria cristata L. revealed the presence of various bioactive phytoconstituents. An acute toxicity study of 50% hydroethanolic leaf extract of Barleria cristata L. reported that at all normal therapeutic doses, the test sample was safe for oral treatment. There was no significant change in the bodyweight of rats. Diabetes was induced in experimental rats by the intraperitonial injection of Alloxan. The 50% hydroethanolic extract of Barleria cristata L effectively lowered the blood glucose level in diabetic rats which was equal to glibenclamide treated rats. The plant extract treated HLD rats showed a dose related hypolipidemic activity. All the lipid components – TC, TG, LDL-C, VLDL-Cholesterol levels were reduced significantly, and HDL-C, protective cholesterol level was increased. The present study clearly indicated that 50% hydroethanolic extract of Barleria cristata L. leaf had produced a hypoglycemic and hypolipidemic effect on both diabetic and HLD fed rats.
K. Amutha * and D. Va Doss
Department of Biochemistry, Rathnavel Subramaniam College of Arts and Science, Sulur, Coimbatore, Tamil Nadu, India.
10 February 2022
14 March 2022
27 April 2022
01 September 2022