EVALUATION OF IMMUNOMODULATORY ACTIVITY OF THE FLAVANOID OF KIGELIA AFRICANAAbstract
Objective: Modulation of the immune responses to alleviate the diseases has been of interest for many years. Thus, a real need exists to protect our immune systems and lead healthier lives. Hence the present study is aimed to evaluate the immunomodulatory activity of the Flavonoid of Kigelia africana (Family: Bignoniaceae). Methods: The assessment of immunomodulatory activity on cell-mediated and humoral mediated immunity were studied by Carbon clearance test; Cyclophosphamide induced neutropenia, Indirect Haemagglutination reaction, Neutrophil adhesion test, and effect on Serum immunoglobulin level. Results: Flavonoid of Kigelia africana was administered orally at a low dose and a high dose of 100mg/kg/day, po and 200 mg/kg/day, po respectively and Levamisole (2.5 mg/kg/day, po) was used as standard drug. Flavonoid of Kigelia africana in both doses showed a significant increase in the phagocytic index in carbon clearance assay, significant protection against Cyclophosphamide induced neutropenia. It also increased the circulating antibody titer in an indirect haemagglutination test and increased the adhesion of neutrophils in the neutrophil adhesion test. Hence, it was concluded that Flavonoid of Kigelia africana increases both humoral immunity and cell-mediated immunity. Conclusion: Flavonoid of Kigelia africana increases both humoral immunity and cell-mediated immunity.
P. K. M. Nagarathna, K. Reena *, S. Reddy and J. Wesley
Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India.
05 March 2014
23 May 2014
13 July 2014
01 October 2014