EVALUATION OF IN-VIVO ANTI-INFLAMMATORY ACTIVITY OF MONO HERBAL SIDDHA FORMULATION KANDUPARANGI CHOORANAM (PYGMAEOPREMNA HERBACEA – ROOT POWDER) IN CARRAGEENAN-INDUCED PAW EDEMA & PLEURISY IN WISTAR ALBINO RATS

Introduction: Monoherbal or polyherbal formulation, which is used in Siddha medication, have a wide variety of phytochemical substances as primary and secondary metabolites, which show many pharmacological activities, including the anti-inflammatory effect. Materials and Methods: The anti-inflammatory activity of Kanduparangi chooranam (KC) was evaluated by using carrageenan-induced paw edema and carrageenan-induced pleurisy Wistar albino rat models. KCwas administered orally at doses such as 100 and 200 mg/kg BW, and it was compared with the standard drug indomethacin (10 mg/kg, body weight). The changes in % of inhibition of paw volume, level of pleural exudates and migratory leukocyte count were noted. Results: In the carrageenan-induced rat paw oedema model, the test drug KC was found to be the paw oedema volume at the dose of 100mg and 200 mg/kg, body weight was 61.94% and 63.05 %, respectively (p<0.001) whereas  Indomethacin which had 65.83% paw volume inhibition. In the carrageenan-induced pleurisy rat models, the test drug KC was found to be values of the pleural exudates level at the dose of 100mg and 200 mg/kg, body weight were0.27±0.12ml and 0.23±0.1ml respectively (p<0.001) whereas Indomethacin which showed 0.21±0.08 ml and as well as the migratory leukocyte count of KC was found to be0.55 ± 0.11 x 10³cells / ml and 0.50 ± 0.10 x 10³cells / ml, respectively (p<0.001) whereas Indomethacin had 0.45±0.08×10³ cells/ml. These results suggest that Kanduparangi chooranam has significant anti-inflammatory activity, which is useful in the management of painful inflammatory conditions.