EVALUATION OF IN-VIVO ANTI-INFLAMMATORY ACTIVITY OF MONO HERBAL SIDDHA FORMULATION KANDUPARANGI CHOORANAM (PYGMAEOPREMNA HERBACEA – ROOT POWDER) IN CARRAGEENAN-INDUCED PAW EDEMA & PLEURISY IN WISTAR ALBINO RATSAbstract
Introduction: Monoherbal or polyherbal formulation, which is used in Siddha medication, have a wide variety of phytochemical substances as primary and secondary metabolites, which show many pharmacological activities, including the anti-inflammatory effect. Materials and Methods: The anti-inflammatory activity of Kanduparangi chooranam (KC) was evaluated by using carrageenan-induced paw edema and carrageenan-induced pleurisy Wistar albino rat models. KCwas administered orally at doses such as 100 and 200 mg/kg BW, and it was compared with the standard drug indomethacin (10 mg/kg, body weight). The changes in % of inhibition of paw volume, level of pleural exudates and migratory leukocyte count were noted. Results: In the carrageenan-induced rat paw oedema model, the test drug KC was found to be the paw oedema volume at the dose of 100mg and 200 mg/kg, body weight was 61.94% and 63.05 %, respectively (p<0.001) whereas Indomethacin which had 65.83% paw volume inhibition. In the carrageenan-induced pleurisy rat models, the test drug KC was found to be values of the pleural exudates level at the dose of 100mg and 200 mg/kg, body weight were0.27±0.12ml and 0.23±0.1ml respectively (p<0.001) whereas Indomethacin which showed 0.21±0.08 ml and as well as the migratory leukocyte count of KC was found to be0.55 ± 0.11 x 103cells / ml and 0.50 ± 0.10 x 103cells / ml, respectively (p<0.001) whereas Indomethacin had 0.45±0.08×103 cells/ml. These results suggest that Kanduparangi chooranam has significant anti-inflammatory activity, which is useful in the management of painful inflammatory conditions.
C. B. S. Bharath Christian
Department of Maruthuvam, Santhigiri Siddha Medical College, Kerala University of Health Sciences, Pothencode, Thiruvananthapuram, Kerala, India.
25 March 2023
14 June 2023
25 August 2023
01 November 2023