EVALUATION OF JASMINUM GRANDIFLORUM FOR HEPATOPROTECTIVE ACTIVITY IN ISONIAZID INDUCED LIVER DAMAGEAbstract
Objectives: The study was designed to evaluate hepatoprotective effect of the ethanolic leaves extract of Jasminum grandiflorum (JG) in Isoniazid (INH) induced hepatotoxicity in wistar albino rats.
Materials and methods: Mature leaves of JG were collected, authenticated and subjected to successive ethanolic extraction. Hepatic damage was induced in wistar rats by administering INH (54mg/kg, p.o.) once a daily for 30 days followed by administration of JG(200mg/kg, p.o.) 1h.prior to the administration of INH (54mg/kg, p.o.) once daily. Silymarin (50mg/kg. p. o) was used as standard for 30 days.
Result: Elevated levels of Aspartate transaminase, Alanine transaminase, and Lipid profile following INH administration were significantly lowered by JGtreatment. Deposition of collagen was observed in liver and found to be less inJG treated animals; Pretreatment of rats with JG significantly decreases Lipid peroxidation (LPO) and increases the antioxidant activities.
Conclusion: The study reveals the hepatoprotective activity of leaves extract of JGin isoniazid induced liver damage.
Netranjali Dhamal, Mihir Patel and Shrikant Pawar*
Department of Pharmacology, Sinhgad Technical Education Society’s Smt. Kashibai Navale College of Pharmacy, Kondhwa, Pune-411048, Maharashtra, India
03 April, 2012
21 May, 2012
19 July, 2012
01 August, 2012