EVALUATION OF PHYTOCHEMICAL SCREENING AND ANTI-FERTILITY ACTIVITY OF CURCUMA AROMATICA SALISBAbstract
The practice of traditional medicine for the control of fertility in most parts of India is based on the uses of plant medicines for many years. The fact that herbal medicines have been employed for such a long time does not guarantee their efficacy and safety. The aim of the present study was, therefore, to carry out phytochemical screening, efficacy and safety studies on one of the traditionally used antifertility plants: Curcuma aromatica Salisb. The secondary metabolites of the rhizomes of this plant were determined. The ethanolic and aqueous extract of the rhizomes of this plant were investigated for their antifertility activity in female rats The identification of the secondary metabolites showed that the rhizomes of the plant contained phytosterols, alkaloids, carbohydrate and saponins. The ethanolic and aqueous extract of this plant at two different doses of 200mg kg -1 and 400 mg kg -1 b.w. prevented the pregnancy. The aqueous extract were found to possess more significant (p<0.001) antifertility activity compared to alcoholic extract. All these observations suggest that the extract has antifertility effect and is safe at the effective antifertility doses employed in this study.
DAS TRISHNA *, MISHRA SHANTI BHUSHAN, BASAK MRINMOY, MOHANTY J.P., SHIL DIBYENDU
Girijananda Institute of Pharmaceutical Sciences, Guwahati (Assam), India
4 December, 2009
20 December, 2009
28 December, 2009
01 January, 2010