EVALUATION OF PORTULACA OLERACEA LINN. FOR HYPOGLYCAEMIC EFFECTS
AbstractHypoglycaemic and anti-hyperglycaemic effects of Portulaca oleracea Linn. (POL) was evaluated in experimental rat models in vivo. The aqueous extract of POL was subjected to preliminary toxicity screening by an acute toxicity study in Wister albino rats. The POL was found to be safe in the doses used and there was no mortality up to a dose of 3000mg/kg orally after 24 hours. Hypoglycaemic effects of POL extract with doses 200mg, 400mg and 800mg were evaluated on Wistar albino rats by using a standard protocol. Anti-hyperglycaemic effect of POL extract with the same doses i.e. 200mg, 400mg and 800 mg were also studied in alloxan induced diabetic albino rats. The aqueous POL extract at doses 800mg showed significant hypoglycaemic effects as compared with a standard drug like glibenclamide. The same doses of POL also showed anti-hyperglycaemic properties in alloxan induced diabetic rats. The present study showed that the aqueous POL extract has hypoglycaemic as well as anti-hyperglycaemic effects.
Article Information
37
1908-1913
375KB
1261
English
IJPSR
Lalromawii*, A. Subhalakshmi Devi , U. Dhamaraj Meetei and R.K. Bharati Devi
Senior Resident, Department of Pharmacology, NEIGRIHMS, Mawdiangdiang, Shillong – 793018, Meghalaya, India
lalromawii@gmail.com
06 December, 2013
26 February, 2014
26 March, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1908-13
01, May 2014
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