EVALUATION OF PRESERVATIVE EFFECTIVENESS OF FERULIC ACID DERIVATIVES IN ALUMINIUM HYDROXIDE GEL- USPAbstract
The selected amide and ester derivatives of ferulic acid were subjected to preservative efficacy testing in an official antacid preparation, (Aluminium Hydroxide Gel-USP) against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans and Aspergillus niger as representative challenging microorganisms as per USP 2004 guidelines. The selected derivatives were found to be effective against all selected strains and showed preservative efficacy comparable to that of standard and even better in case B. subtilis and C. albicans. The 8- hydroxy quinoline ester derivative showed better preservative efficacy than standard as well as other derivatives and have better potential for use in the pharmaceutical preparations.
Anurag Khatkar, Arun Nanda* and Balasubramanian Narasimhan
Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, Haryana, India
08 March, 2013
21 April, 2013
24 June, 2013
01 July, 2013