EVALUATION OF RAMIPRIL ON BLOOD SUGAR LEVEL AND INTERACTION WITH THE ORAL ANTI-DIABETIC DRUGS IN ALLOXAN-INDUCED DIABETIC RATSAbstract
Aim: The present study investigates the effect of Ramipril on blood sugar level and interaction with the oral anti-diabetic drugs in alloxan induced diabetic rats.
Method: Rats were divided into 10 groups (n = 6) where Group I –II were normal and Group III –X were diabetic. Ramipril at the dose of 0.9 mg/kg body weight were administered to the normal and diabetic rats. In diabetic groups, the Ramipril was given concomitantly with the each of three Oral anti-diabetic drugs to find-out the effect on blood sugar level .All drugs administered orally once a day for 13 days and at the end of the experimentation Oral Glucose Tolerance Test (OGTT) was conducted.
Results: It was observed that in normal rats the Ramipril slightly reduced the blood sugar level which was insignificant (P>0.05) except at ‘30’ min time point. In contrast in, it exhibited the anti-hyperglycemic activity significantly (P≤0.01) at all-time points in alloxan induced diabetic rats.
Conclusion: The present study has concluded that The Ramipril has significant anti-hyperglycemic activities which accentuate the effect of oral anti-diabetic drugs in alloxan-induced diabetic rats.
Neeraj K. Agrawal* and Uma Gupta
Assistant Professor, Department of Pharmacology, HIHT University, Dehradun , India
19 March, 2013
09 May, 2013
15 July, 2013
01 August, 2013