EVALUATION OF RATIONAL DRUG USE AND EFFICACY OF VARIOUS COMBINATIONS OF ANTIHYPERTENSIVE DRUGS COMMONLY PRESCRIBED FOR THE MANAGEMENT OF HYPERTENSION IN CKD PATIENTS AT TERTIARY CARE HOSPITALAbstract
To evaluate the rational drug use and efficacy evaluation of various combinations of Antihypertensive drugs commonly prescribed for the management of hypertension in CKD patients at tertiary care hospitals. This is an observational and comparative study. A randomized trial was carried out in 300 patients after obtaining the consent for 1 year in a tertiary care hospital in Mahabubnagar. The data collection form was prepared and used. This form mainly contains the patient’s demographic details and medication chart with diagnosis. Also, prescription pattern of the patient, daily usage of antihypertensive. Antihypertensive, antacids and anti-diabetics were the most prescribed drugs. A substantial number of drugs prescribed to patients with CKD were not appropriately adjusted. Inappropriate prescribing was associated with ADRS, and drug interactions. In the study, six antihypertensive combinations were observed in that CCB’s were the most frequently prescribed drug category in patients with HTN and CKD.
Sana Butool *, Faheemuddin and Musarrath Mubeen
Department of Pharmacology, Smt. Sarojini Ramulamma College of Pharmacy, Mahabubnagar, Telangana, India.
21 December 2021
03 February 2022
28 April 2022
01 August 2022