EVALUATION OF RENAL EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF PORTULACA OLERACEA (WHOLE PLANT) IN ALLOXAN INDUCED DIABETIC RATSAbstract
Herbal plants are effective in the treatment of various diseases. More or less they are unscientifically and improperly used. These plants deserve detailed studies in the light of modern medicine. Having detailed investigation and documentation of herbal plants used in local health traditions and after that doing pharmacological evaluation of these plants and their taxonomical classification can lead to the development of valuable plant drugs for many diseases. In the present study, the renal effects of hydro-alcoholic extract of Portulaca oleracea (whole plant) were evaluated by performing the kidney function tests. Firstly the hydro-alcoholic extract of the plant was made. Rats were made diabetic by a single dose of 120 mg/kg b.w. After observing them for 72 hours, the blood glucose levels were checked. The rats having blood glucose levels above 200 mg/dl were taken for the study. The extract was first subjected to preliminary phytochemical screening. The doses taken were 100 and 200 mg/kg b.w. Phytochemical screening showed the presence of many plant constituents. The effect of the extracts on kidneys was evaluated, which showed variable results.
S. Shafi * and N. Tabassum
Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, Kashmir, Jammu & Kashmir, India.
26 July, 2017
27 October, 2017
17 November, 2017
01 May, 2018