EVALUATION OF THE HAEMATOLOGICAL AND BIOCHEMICAL EFFECTS OF AVERON®, A HERBAL FORMULATION, AGAINST CYCLOPHOSPHAMIDE-INDUCED IMMUNOMODULATED MALE RATSAbstract
The study was carried out to evaluate the immunomodulatory activity and the effect on the biochemical parameters of Averon®, an herbal formulation, on cyclophosphamide induced immunosuppression in rats. Haematological and biochemical parameters were evaluated after 21 days on blood samples collected by retro-orbital puncture at sacrifice. Results showed that death occurred in the immunosuppressed groups before collection of blood by retro-orbital puncture whereas in the immunoprophylactic groups, there was a minimal dose-boosting effect of the white blood cells that was statistically significant. There was no significant statistical difference in alkaline phosphatase, total bilirubin, cholesterol, high density lipoproteins, low density lipoproteins, triglycerides and total proteins (p≤0.05). However, a statistical significant difference was seen in the alanine aminotransferase and creatinine levels (p≤0.05) and aspartate aminotransferase (p≤0.001). Averon® is thus said to be better suited as an immunoprophylactic herbal formulation than immunostimulatory with better immunoboosting effects at higher doses (>400mg/kg) in the order of 800mg/kg and above.
G.E. Ukpo*, T.S. Ehianeta , A.Y. Adegoke and O.A. Salako
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, P. M. B 12003, Lagos, Nigeria
12 April, 2013
12 July, 2013
30 August, 2013
01 September, 2013