EVALUATION OF THE IMMUNOMODULATORY ACTIVITY OF THE ROOTS OF ICHNOCARPUS FRUTESCENS
AbstractThe objective of the present study was to investigate the immunomodulatory activity of the roots of Ichnocarpus frutescents R.Br. In the present study Pet. Ether, Chloroform and Methanolic fractions of the ethanolic extract of the roots of Ichnocarpus frutescens, in the doses of 10mg/kg and 30mg/kg, were administered orally to evaluate the immunomodulatory activity. The Methanolic fraction in the dose of 30mg/kg showed most significant effect when compared with control group, in the E.Coli induced abdominal sepsis and Carbon Clearence Test as models for non-specific immune response. In the models of the Specific immune response, in cell mediated immune response to SRBC – delayed type of hypersensitivity (DTH) the Methanolic fraction in the dose 30 mg/kg showed most significant effect on decrease in footpad edema after treatment when compared with control group. Humoral immune response was assessed by Sheep erythrocyte agglutination test, in which the Methanolic fraction of IF 30mg/kg showed most significant (p<0.05) increase in antibody titer after treatment when compared with control group. The present investigation reveals that the Methanolic fraction of the ethanolic extract of the roots of Ichnocarpus frutescens, in the dose of 30mg/kg possesses most significant immunomodulatory activity
Article Information
13
1438-1444
458
1082
English
Ijpsr
V. R. Patil, V. M. Thakare and V. S. Joshi*
Department of Pharmacognosy, Hon’ble Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, Dist- Jalgaon, Maharashtra, India
vipinsjoshi@yahoo.com
05 July, 2014
13 March, 2015
17 March, 2015
10.13040/IJPSR.0975-8232.6(4).1438-44
01 April, 2015