EVALUATION OF THE NEUROBEHAVIOURAL ACTIVITIES OF CRUDE LEAF EXTRACTS OF SARCOCEPHALUS LATIFOLIUS AND ITS EFFECT ON MICROANATOMY OF TEMPORAL LOBE OF ADULT WISTAR RATS
AbstractSarcocephalus latifolius have a wide range of medicinal applications. This study evaluated the neurobehavioural activity of crude Leaf extract of Sarcocephalus latifolius on wistar rats and the effect on the histoarchitecture of the temporal lobe. Sixteen adult Wistar rats were divided into four groups of four rats each. Group A served as the negative control and received distilled water, B and C served as the experimental group and received 100mg/kg and 150mg/kg of the extract, while D served as the positive control and received 2.5mg/kg of diazepam. The administration lasted for two weeks and the neurobehavioural activity of the extract was explored using elevated plus maze. After the test the rats were sacrificed and the brain harvested, fixed and processed using normal histological techniques. In the elevated plus maze, the experimental group showed increased open entry, when compared to the negative control but less than the positive control, which is a measure of its anxiolytic activity. The extracts altered the microanatomy of the temporal lobe, in dose dependent manner. In conclusion the extract has anxiolytic property and modified the microanatomy of the temporal lobe.
Article Information
14
1128-1134
913 KB
335
English
IJPSR
Okoronkwo Samuel Okafor *, Anyanwu, Gabriel Emeka, Uchewa, Obinna Onwe, Okoronkwo, Akudo Christain and John E. Abraham
Department of Anatomy, Faculty of Basic Medical Sciences, David Umahi Federal University of Health Sciences, Uburu Ebonyi State, Nigeria.
okoronkwosam1@gmail.com
29 August 2023
10 November 2023
15 November 2023
10.13040/IJPSR.0975-8232.15(4).1128-34
01 April 2024
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