EVALUATION OF THE NEUROPROTECTIVE ACTIVITY AND COGNITIVE ABILITY OF AEGLE MARMELOS ETHANOLIC LEAVES EXTRACT AND ESTROGEN IN ESTROGEN COMPROMISED FEMALE RATS USING SCOPOLAMINE-INDUCED ALZHEIMER’S MODEL
AbstractAlzheimer’s disease, the most common form of dementia, is higher in elderly women than men. Escape latency time of Group 3 (Donepezil) and Group 6 (AMEE and Estradiol) is less than group 2 (Scopolamine and letrozole). As shown by the results, the decrease in AChE level in Group 3 (Donepezil) and Group 6 (AMEE and Estradiol) indicates restoration of Ach level in the brain. Increased GSH level was seen in Group 3 (Donepezil) and Group 6 (AMEE and Estradiol16 indicating antioxidant property. The architecture of the neurons in the hippocampus histopathological studies was seen when the combined treatment with estrogen and AMEE was given confirming that our given combination has the potential to improve memory in female rats, particularly those who were estrogen-deficient as in our experimental design. Based on our experiments, we can conclude that Aegle marmelos ethanolic extract, along with estradiol, can improve memory and can be used for further studies in this area.
Article Information
17
3960-3968
1262 KB
331
English
IJPSR
R. Taniya *, S. Uniyal and C. Malvika
School of Pharmaceutical Sciences, Shri Guru Ram Rai University Dehradun, Uttarakhand, India.
taniyarawat101997@gmail.com
16 February 2022
12 April 2022
25 April 2022
10.13040/IJPSR.0975-8232.13(10).3960-68
01 October 2022
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