EVALUATION OF THROMBOLYTIC AND MEMBRANE STABILIZING ACTIVITIES OF FOUR MEDICINAL PLANTS OF BANGLADESHAbstract
The crude methanol extracts of aerial parts ofAbrus precatorius L., leaf of Magnolia pterocarpa Roxb. and Dracaena spicata Roxb. and leaf and bark ofRavenala madagascariensis Sonn. as well as their hexane, carbon tetrachloride, chloroform and aqueous soluble partitionates were subjected to screenings for thrombolytic and membrane stabilizing activities. Among the extractives of A. precatorius, the crude methanol extract exhibited the highest thrombolytic activity (34.92±0.54 %) while the carbon tetrachloride soluble fraction of M. pterocarpa exhibited 22.59±0.88 % clot lysis. D. spicata extractives showed mild thrombolytic activity. The methanolic crude extract of R. madagascariensis leaf and the aqueous soluble fraction of R. madagascariensis bark extract showed 45.32±0.82 % and 32.67±0.74% clot lysis, respectively. In hypotonic solution and heat induced conditions, the crude methanol extract of A. precatoriusand the hexane soluble fraction of crude methanol extract of M. pterocarpa inhibited 63.46±0.84 % & 36.54±0.21 % and 66.12±0.66 % & 40.54±0.02 % haemolysis of RBCs, respectively as compared to 71.90 % and 42.12 % inhibition by acetyl salicylic acid (0.10 mg/ml), respectively. The crude methanol extract of D. spicata demonstrated 64.44±0.68 % and 36.52±0.19 % inhibition of hypotonic solution and heat induced hemolysis, respectively. The chloroform soluble fraction of R. madagascariensis leaf extract demonstrated 28.72±0.61 % & 39.97±0.39 % and the hexane soluble fraction of R. madagascariensis bark extract revealed 53.78±0.17 % & 41.83±0.61 % inhibition of hypotonic solution and heat induced hemolysis of RBCs, respectively.
S.R. Chowdhury, T. Sharmin*, M. Hoque, Md. Sumsujjaman, M. Das and F. Nahar
Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh
16 June, 2013
10 August, 2013
22 October, 2013
01 November, 2013