EVALUATION OF WOUND HEALING ACTIVITY OF ZIZIPHUS XYLOPYRUS (RETZ) WILLD LEAVES EXTRACT IN WISTAR ALBINO RATS
AbstractAim: The present study provides a scientific evaluation for the wound healing activity of methanolic extract of Ziziphus xylopyrus (Retz) Willd leaves (MEZX). Methods: Incision and excision wound models were used to evaluate the wound healing activity of MEZX on Wistar rats. In each model, animals were divided into four groups of 6 animals each. In both model, Group I was assigned as control (ointment base). Group II and III were treated with 5%w/w and 10% w/w MEZX topical ointment respectively. Group IV was treated with standard nitrofurazone ointment (0.2% w/w). The parameters recorded were percentage of wound contraction, epithelialisation period and tensile strength. Results: It was noted that the effect produced by MEZX ointment showed significant (P < 0.001) healing in all wound models when compared with the control group. All parameters such as wound contraction, epithelialisation period and tensile strength showed significant (P < 0.001) changes when compared with the control. MEZX stimulates wound contraction, decreases epithelialisation period and increases tensile strength. Conclusion: This study suggests that MEZX possesses wound healing activity against Incision and excision wound.
Article Information
41
1287-1293
410
897
English
IJPSR
Talha Jawaid *, Mehnaz Kamal, Abha Kumari and Kuldeep Singh
Department of Pharmacology, Hygia Institute of Pharmaceutical Education and Research, Ghaila Road, Lucknow, Uttar Pradesh, India.
talhajawaid78@gmail.com
27 August, 2016
14 October, 2016
19 October, 2016
10.13040/IJPSR.0975-8232.8(3).1287-93
01 March, 2017
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