EVALUTION OF ANTI-DIABETIC ACTIVITY OF METHANOL EXTRACT OF DIGERA MURICATA (L) MART IN ALLOXAN INDUCED DIABETIC RATSAbstract
Digera muricata (L.) Mart (Amaranthaceae) commonly known as Cancali soppu widely used in traditional system of medicine for the treatment of diabetes mellitus In the present study, Methanol extract of Digera muricata(MEDM) leaves were subjected to phytochemical investigation and evaluated for antidiabetic activity in alloxan induced diabetic rats. MEDM (100, 200 mg/kg) and Glibenclamide (3mg/kg) were administered orally in alloxan (140 mg/kg, i.p.) induced diabetic rats. In acute oral toxicity (OECD Guide line 423) study, administration of MEDM no mortality upto 2000 mg/kg was observed. OGTT, Fasting blood glucose level, body weight, lipid profiles, HbA1c, plasma insulin, and ALP were evaluated in normal and diabetic rats. preliminary phytochemical investigation revealed the presence of alkaloids, flavonoids, glycosides, tannins as the major constituents in the methanol extract .These results suggest that MEDM (200mg/kg) showed antihyperglycemic activity in alloxan induced diabetic rats.
G. Jagatha* and N. Senthilkumar
Department of Pharmaceutical Chemistry, JKKMMRF College of Pharmacy, Komarapalayam, Namakkal Dist., Tamil Nadu, India
08 March, 2011
28 March, 2011
28 May, 2011
01 June, 2011