EVALUTION OF ANTI-UROLITHIATIC ACTIVITY OF RICINUS COMMUNIS L. LEAVESAbstract
The present investigation was under taken to evaluate the anti-urolithiatic activity of ethanolic extract of Ricinus communis leaves in experimental animals. Ricinus communis Leaves were evaluated for anti-urolithiatic activity using Urolithiasis is a common disorder with higher recurrence rate in men. Super saturation of crystals with imbalance between levels of promoters and inhibitors of stone formation results in urolithiasis. Current medical management of urolithiasis is either costly or not without side effects. Therefore, traditionally reported more effective and safer anti-urolithiatic medicinal plants need to be studied. Thus, this study was aimed to evaluate the anti-urolithiatic activity of ethanolic extract of Ricinus communis leaves in male albino wistar rats. Ethylene glycol (0.75% v/v in drinking water; 28 days) induced urolithiasis preventive model were used to study the effect Ricinus communis leaves dose (200 mg/kg) and. Cystone (750 mg/kg) was used as a standard. At the end of the treatment changes in various physical parameters, promoters, inhibitors, renal function markers in urine and serum samples and histopathology of kidneys were observed. All the treatments significantly prevented the rise in promoters like calcium, oxalate, uric acid, and inorganic phosphate and increased the levels of magnesium and citrate like inhibitors in various biological samples. Thus ethanolic extract of Ricinus communis leaves have proved to be an effective drug in prevention of urolithiasis.
R. Dahiya*, U. K. Gilhotra and A.K. Verma
Department of Pharmacology, G. D. Memorial College of Pharmacy, Jodhpur, Rajasthan India.
23 March, 2017
19 May, 2017
17 September, 2017
01 November, 2017