EVALUTION OF ANXIOLYTIC ACTIVITY OF LEPTADENIA RETICULATA PLANTAbstract
The persent study was designed to investigate the anxiolytic activity of ethanolic extract of Leptadenia reticulata plant. It is a folk medicine traditionally used in treatment of eye diseases, seminal debility, general weekness, cough, fever, asthma, sore throat and gonorrhea. The anxiolytic activity was evaluated by Elevated plus maze Test, Light-Dark Test, Hole-board Test and Social-intraction Test models by using Wistar albino rats. The extract at oral dose 200mg/kg and 400mg/kg at body weight significantly increased time spend and no of entries in open arms in Elevated plus maze test and time spend in light area in light-dark test and no of head dipping in hole board test and also inceased social interaction time in social interaction test as compard to control animals. The effect was compared to the Diazepam (2mg/kg i.p.) as standard anxiolytic drug. The result of study indicate that the Leptadenia reticulata plant have potant anxiolytic activity.
Bhawna Rajpurohit *, Umesh K. Gilhotra, Anil K Verma and Chandan Genwa
G. D. Memorial College of Pharmacy, Jodhpur-342005, Rajasthan, India
25 June, 2016
06 September, 2016
07 October, 2016
01 December, 2016