EVOLVING KNOWLEDGE IN FRAMING OF TERATOGENIC ACTIVITY TOWARDS RISK PERCEPTIONAbstract
Birth defects induced by maternal exposure to exogenous agents during pregnancy are preventable if the agents themselves can be identified and avoided. This might be the causative effect in mechanical fetal diseases and retarded in the development of embryo and fetus. Often, the safety of a drug in the mother’s fetuses and nursing infants cannot be determined until it has been widely used. This represents a particular case of an embryo with their abnormalities in the development of physiological induction and structural disorders in their progeny, by these consequences in occurrence with some agent’s leads to teratogenicity. These causative agents are may be chemical or physical, and some inhibit the nature of retardation in growth caused by ionization radiation, oxidative stress, etc. These malformations in neonates are majorly caused by the placental transfer of drugs from maternal-fetal circulation. The current review critically explores the issues of several classes of medication during gestation and seeking to promote general and concise resources used during pregnancy and lactation.
A. D. Paul *, V. M. Prathap and A. Chandrakala
Department of Pharmaceutics, SVU College of Pharmaceutical Sciences, SV University, Tirupati, Andhra Pradesh, India.
04 December 2019
23 April 2020
26 July 2020
01 August 2020