EXPLORATION OF AMORPHOPHALLUS PAEONIIFOLIUS STARCH AS NATURAL BINDERAbstract
The aim of the present work was to characterize the starchy components of Amorphophallus paeoniifolius tuber and evaluate its potential as a binder. The tuber starch was extracted and characterized in terms of Phyto-chemical and physicochemical properties. Cyproheptadine was selected as model drug, and drug excipient compatibility studies were carried. Granules containing 5%, 7.5%, 10%, and 12.5% of isolated starch were prepared by wet granulation and evaluated for pre and post-compression parameters. The isolated sample was white in color and free from contaminant with moderate flow properties. The drug was found to be compatible with excipients, as revealed in the FTIR study. Prepared granules were found to have good flow property and compressibility as evident from the angle of repose and Carr’s compressibility index. The tablets were also evaluated for hardness, friability, disintegration time and in-vitro dissolution and all the result were found to be in the standard limit as per I.P. Results shows that Amorphophallus paeoniifolius starch can be used as a tablet binder and could be effectively utilized as a multi-functional natural excipient.
U. Y. Kandekar * and T. R. Abhang
JSPM’s Rajarshi Shahu College of Pharmacy and Research, Tathwade, Pune, Maharashtra, India.
01 December 2019
08 April 2020
20 November 2020
01 December 2020