EXPLORATION OF ANTI-HYPERGLYCEMIC POTENTIAL OF HERBAL MIXTURE IN STREPTOZOTOCIN-INDUCED TYPE-II DIABETES IN RATSAbstract
Indigenous plants like Withania coagulans fruits. Alstonia scholaris bark and Aegle marmelose leaves have been used for diabetes management by traditional Indian people for a long time. The present study was carried out to investigate anti-hyperglycemic potential of an herbal mixture comprising of extracts of these three plants in streptozotocin-induced diabetes in Wistar rats and to focus on its possible mechanism of action. Experimental diabetes was induced in Wistar rats by a single intraperitoneal injection of streptozotocin (65 mg/kg). Animals were divided in five groups (n=6) and treated with herbal mixture (100 & 200 mg/kg) for 4 weeks. At the end of the study period, fasting blood glucose, oral glucose tolerance, glycol-sylated hemoglobin, serum insulin, glucose uptake from rat hemidiaphragms, and liver glycogen were determined. Antioxidant enzymes of the liver, including superoxide dismutase and catalase, were evaluated. Histopathology of the pancreas was studied. The results of our study demonstrate anti-hyper-glycemic and antioxidant potential of the herbal mixture, justifying its use in the indigenous system of medicine.
D. D. Bandawane *, P. D. Chaudhari and A. R. Juvekar
Department of Pharmacology, PES’s Modern College of Pharmacy, Sector - 21, Yamunanagar, Nigdi, Pune, Maharashtra, India.
25 January 2021
09 May 2021
28 May 2021
01 December 2021