EXPRESSION PATTERN OF BETA DEFENSIN-3 IN THE SMALL INTESTINE OF ZEBRA FISH DANIO RERIOAbstract
The vertebrate immune system is composed of numerous distinct and interdependent components, and it consists of both systemic and mucosal immune compartments, but the mucosal immune system which protects the body from the first encounter of pathogens. β-defensins are a group of cysteine-rich cationic antimicrobial peptides that play an antimicrobial roles in the immune systems of vertebrates. Vertebrate defensins can be classified into α-, β, and θ-defensins based on their cysteine disulphide bonding. In the present study, we report the expression level of the β-defensin- 3 in the small intestine of the zebrafish after a bacterial challenge with Staphylococcus aureus with 100% and 50% concentrations. The results revealed that the β-defensin-3 was highly upregulated in both 100% and 50% concentration of the bacterial pathogen, and it plays an important role in the innate and mucosal immunity in zebrafish.
R. C. Shaila *, P. Kathireswari and K. Saminathan
Department of Zoology, Kongunadu Arts and Science College, Coimbatore, Tamil Nadu, India.
20 November 2019
22 May 2020
22 October 2020
01 November 2020