EXTENDED RELEASE FORMULATION OF THEOPHYLLINE USING MODIFIED FENUGREEK GUM AS A HYDROPHILIC POLYMER

The aim of current research work was to develop sustain release formulation of Theophylline. Modified plant derived Fenugreek gum (FG) polymer was synthesized and used as matrix forming agent. Matrix tablet formulations were prepare by wet granulation technique using modified fenugreek gum in different concentration. The prepared formulations were evaluated for physical properties such as tablet hardness, weight variation, drug content and In vitro drug release. Formulation prepared with drug: polymer weight ratio of 1:2 showed desired release profile as per USP specification.  FTIR study showed absence of chemical interaction between drug and polymer. The optimized formulation was found to show stability for two month as per ICH guideline. Study suggested that modified fenugreek gum can be used as extended release polymer.