EXTENDED RELEASE FORMULATION OF THEOPHYLLINE USING MODIFIED FENUGREEK GUM AS A HYDROPHILIC POLYMERAbstract
The aim of current research work was to develop sustain release formulation of Theophylline. Modified plant derived Fenugreek gum (FG) polymer was synthesized and used as matrix forming agent. Matrix tablet formulations were prepare by wet granulation technique using modified fenugreek gum in different concentration. The prepared formulations were evaluated for physical properties such as tablet hardness, weight variation, drug content and In vitro drug release. Formulation prepared with drug: polymer weight ratio of 1:2 showed desired release profile as per USP specification. FTIR study showed absence of chemical interaction between drug and polymer. The optimized formulation was found to show stability for two month as per ICH guideline. Study suggested that modified fenugreek gum can be used as extended release polymer.
Ajay Kumar Sav*, Parag Kapadi , Sanjeev Shukla and Purnima Amin
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai-400019, Maharashtra, India
28 August, 2013
10 October, 2013
26 December, 2013
01 January, 2014