EXTRACTIVE SPECTROPHOTOMETRY METHOD FOR ESTIMATION OF ROSIGLITAZONE IN PHARMACEUTICAL FORMULATIONS USING BROMOTHYMOL BLUE
AbstractAn accurate and precise method was developed for Rosiglitazone Maleate in the visible range of electromagnetic spectrum sing Bromothymol Blue (BTB) in alkaline medium resulting in a blue chromogen showing its absorption maxima at 615 nm. Sandell’s sensitivity to the proposed method was found to be 1.5 × 10-4 µg/ml. The extracted complexes obey Beer–Lambert’s law in the concentration range of 1 to 30 µg/ml. The effect of the concentration of dye and pH have been studied and optimized. All the methods were validated as per ICH guidelines. The methods have been applied to the determination of drug in commercial tablets, and results of the analysis were validated statistically through recovery studies.
Article Information
60
3995-3998
591
1119
English
IJPSR
L. Adhikari *, M. Mukherjee and S. Nayak
School of Pharmaceutical Sciences, S. O. A. University, Ghatikia, Bhubaneswar, Odisha, India.
lopamudraadhikari@gmail.com
01 March 2014
07 June 2014
28 June 2014
10.13040/IJPSR.0975-8232.5(9).3995-98
01 September 2014
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