FABRICATION AND CHARACTERIZATION OF CICLOPIROX OLAMINE LOADED NONIONIC SURFACTANT BASED NIOSOMES FOR TOPICAL DELIVERYAbstract
A number of strategies to deliver antifungal using nanocarriers are developed to facilitate drug targeting infected cells that result in improved antifungal activity. Objective: Ciclopirox olamine has a broad spectrum of action against dermatophytes, yeasts, filamentous fungi and bacteria. It has a biological half-life of 1.7 h and bioavailability of < 5% with prolonged use. A remarkable feature of the drug is that no single case of fungal resistance has been reported so far. Therefore, ciclopirox olamine loaded niosomes entrapped in suitable gel delivery systems may successfully deliver the drug for prolonged time in treatment of fungal infection. Material and Method: A Ciclopirox Olamine loaded niosomes were developed using various surfactants along with cholesterol in different proportions by ether injection and film hydration method. The prepared niosomes were evaluated for various characteristics such as shape and size, entrapment efficiency, in-vitro drug release studies. Result and Discussion: Among all, formulation CNFS61 showed optimal drug release with maximum entrapment efficiency having smaller vesicular size. So, formulation CNFS61 was considered as promising formulation and further characterized with respect to TEM, SEM, Zeta potential, Polydispersity index, vesicle properties and particle size diameter by Particle Sizer Analyzer (Malvern). Conclusion: It was concluded that the niosomal formulations of Ciclopirox Olamine can be successfully prepared by ether injection and film hydration method using different surfactants and also the results were revealed that all the formulation showed sustain drug release rate for 24 h.
G. G. Keshavshetti * and S. B. Shirsand
Department of Pharmaceutics, SVET’s College of Pharmacy, Humnabad, Bidar, Karnataka, India.
02 June 2019
11 October 2019
30 November 2019
01 April 2020