FABRICATION, CHARACTERIZATION AND PHARMACOLOGICAL ACTIVITY OF USNIC ACID LOADED NANOPARTICLES
AbstractUsnic acid is lichen metabolite. Lichen species are the source of usnic acid. It has Antitumor and Anti-proliferation activity. Usnic acid is poorly water soluble drug. So its dissolution and bioavailability is poor. To enhance dissolution and bioavailability of usnic acid nanotechnology has been adopted. So in this study usnic acid powder was formulated as a nanoparticle with the help of PLGA polymer. Nano-precipitation with sonication method was adopted to formulate usnic acid loaded nanoparticles. Obtained nanoparticles were undergone to characterization and evaluation studies. SEM study revealed that particles are in the range of nanometer level and it is in spherical shape. FTIR and DSC studies have shown that no interaction between drug and polymer. In vitro drug release was maximum for optimized formulation. Optimized formulation also exhibited more antitumor activity than free usnic acid. Kinetic study revealed that the drug release is zero order. It concludes nano-precipitation with sonication is effective method for preparation of usnic acid loaded nanoparticles.
Article Information
31
4758-4766
684
1184
English
IJPSR
M. S. Pandian, S. C. Karthikeyini* and M. Nagarajan
Anna University, Thiruchirappalli, Tamil Nadu, India.
chithirraanbalaghan@gmail.com
26 March, 2017
11 August, 2017
10 September, 2017
10.13040/IJPSR.0975-8232.8(11).4758-66
01 November, 2017
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