FERTILITY EFFECT OF CYCAS CIRCINALIS AND IONIDIUM SUFFRUTICOSUM IN ALCOHOL INDUCED STERILITY OF MALE WISTAR RATS – AN HISTOMORPHOMETRIC STUDYAbstract
Alcohol abuse is well known to impair reproductive performances due to impaired testosterone production and testicular atrophy. Many natural nontoxic herbs were found to enhance the fertility in male. The study is done to evaluate the effect of Cycas circinalis (Cc) and Ionidium suffruticosum (Is) in improving the fertility of alcohol induced sterile male albino rats. A total of 30 healthy young male albino rats were selected. A total of 24 rats were subjected to 3gm of ethanol/kg body weight/day orally for 4 weeks for experimental rats. Cc and Is extract 200mg/kg body weight were administered orally to the experimental albino rats E-I (n=6) and E-II (n=6) respectively and compared to the positive control albino rats PC (n=6) which was administered testosterone 10µg/kg body weight subcutaneously, biweekly with that of the alcohol induced sterile control rats SC (n=6) using various parameters such as sexual behavior, weight of animals, dimension and weight of testes, hormone, semen, and histological analysis. Restitution of fertility was compared with the normal fertile controls rats NC (n=6). The drug’s efficacy was compared by one way ANOVA among the groups and both the herbs showed significant improvement in all the parameters in experimental rats when compared to control rats. The herbs were found to be effective on the gonads of alcohol induced sterile male albino rats. The synthetic hormonal preparations have grave side effects it’s better to go with herbal aphrodisiacs for better results without any side effects. The study done in animal if extended in humans and if found to be equally effective; will turn out to be a boon for infertile couples who were anxious to conceive.
B. Senthil Kumar
Department of Anatomy, Vinayaka Mission’s Kirupananda Variyar Medical College and Hospital, Salem, Tamilnadu, India
05 August, 2016
28 September, 2016
21 November, 2016
01 February, 2017